Difluoromethylene (CF2)-skipped 1,4-diynes are a versatile synthon in organic synthesis, but efficient methods to access such a fluorinated structural motif are very limited. Herein, we report an efficient method for catalytic synthesis of CF2-skipped 1,4-diynes through palladium-catalyzed cross-coupling between terminal alkynes and gem-difluoropropargyl bromide

More details:http://pubs.acs.org/doi/abs/10.1021/acscatal.6b03216